Model Name: Arabidopsis - starch and the circadian clock, Model 3 (Seaton et al., 2013)

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A model of the circadian regulation of starch turnover, as published in Seaton, Ebenhoeh, Millar, Pokhilko, "Regulatory principles and experimental approaches to the circadian control of starch turnover",  J. Roy. Soc. Interface, 2013. This model is referred to as "Model Variant 3".

Contact/Model Admin Daniel Seaton, ,
Submitted By Daniel Seaton, ,
Submission Date 2013-11-21 15:30:23.0
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Journal Journal of the Royal Society Interface 
Title Regulatory principles and experimental approaches to the circadian control of starch turnover 
Year 2013 
Authors Seaton, Ebenhoeh, Millar, Pokhilko 
Abstract In many plants, starch is synthesised during the day and degraded during the night to avoid carbohydrate starvation in darkness. The circadian clock participates in a dynamic adjustment of starch turnover to changing environmental conditions, through unknown mechanisms. We used mathematical modelling to explore the possible scenarios for the control of starch turnover by the molecular components of the plant circadian clock. Several classes of plausible models were capable of describing the starch dynamics observed in a range of clock mutant plants and light conditions including discriminating circadian protocols. Three example models of these classes are studied in detail, differing in several important ways. First, the clock components directly responsible for regulating starch degradation are different in each model. Second, the intermediate species in the pathway may play either an activating or inhibiting role on starch degradation. Third, the system may include a light-dependent interaction between the clock and downstream processes. Finally, the clock may be involved in the regulation of starch synthesis. We discuss the differences among the models’ predictions for diel starch profiles and the properties of the circadian regulators. These suggest additional experiments to elucidate the pathway structure, avoid confounding results, and identify the molecular components involved.